ICD-10 · PDGM grouping
E70-E88 — Metabolic disorders
Every ICD-10-CM code in this range and the PDGM clinical group CMS assigns to it, read from the CMS grouper crosswalk v07.2.26.
ICD-10-CM FY2027 · CMS grouper v07.2.26
Codes in range
286
No clinical group
7
A period cannot be grouped from these.
Barred as primary
1
CMS rejects these in the primary position.
Where these codes group
262 of the 286 codes in E70-E88 group to MMTA - Other, but the range is not uniform — it spreads across 4 clinical groups. A further 7 are assigned no clinical group at all, which means a 30-day period cannot be grouped from them.
Code families in E70-E88
One page per three-character family: every code in it, whether it can lead a claim, its clinical group and comorbidity subgroup.
- E70Disorders of aromatic amino-acid metabolism26 codes
- E71Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism38 codes
- E72Other disorders of amino-acid metabolism31 codes
- E73Lactose intolerance4 codes
- E74Other disorders of carbohydrate metabolism24 codes
- E75Disorders of sphingolipid metabolism and other lipid storage disorders26 codes
- E76Disorders of glycosaminoglycan metabolism12 codes
- E77Disorders of glycoprotein metabolism4 codes
- E78Disorders of lipoprotein metabolism and other lipidemias18 codes
- E79Disorders of purine and pyrimidine metabolism7 codes
- E80Disorders of porphyrin and bilirubin metabolism10 codes
- E83Disorders of mineral metabolism31 codes
- E84Cystic fibrosis5 codes
- E85Amyloidosis9 codes
- E86Volume depletion3 codes
- E87Other disorders of fluid, electrolyte and acid-base balance14 codes
- E88Other and unspecified metabolic disorders24 codes
Every code in E70-E88
Descriptions are CMS’s own, abbreviated as CMS abbreviates them.
| Code | Description | Clinical group | Primary position |
|---|---|---|---|
| E700 | Classical phenylketonuria | A | Can lead a claim |
| E701 | Other hyperphenylalaninemias | A | Can lead a claim |
| E7020 | Disorder of tyrosine metabolism, unspecified | A | Can lead a claim |
| E7021 | Tyrosinemia | A | Can lead a claim |
| E7029 | Other disorders of tyrosine metabolism | A | Can lead a claim |
| E7030 | Albinism, unspecified | A | Can lead a claim |
| E70310 | X-linked ocular albinism | A | Can lead a claim |
| E70311 | Autosomal recessive ocular albinism | A | Can lead a claim |
| E70318 | Other ocular albinism | A | Can lead a claim |
| E70319 | Ocular albinism, unspecified | A | Can lead a claim |
| E70320 | Tyrosinase negative oculocutaneous albinism | A | Can lead a claim |
| E70321 | Tyrosinase positive oculocutaneous albinism | A | Can lead a claim |
| E70328 | Other oculocutaneous albinism | A | Can lead a claim |
| E70329 | Oculocutaneous albinism, unspecified | A | Can lead a claim |
| E70330 | Chediak-Higashi syndrome | A | Can lead a claim |
| E70331 | Hermansky-Pudlak syndrome | A | Can lead a claim |
| E70338 | Other albinism with hematologic abnormality | A | Can lead a claim |
| E70339 | Albinism with hematologic abnormality, unspecified | A | Can lead a claim |
| E7039 | Other specified albinism | A | Can lead a claim |
| E7040 | Disorders of histidine metabolism, unspecified | A | Can lead a claim |
| E7041 | Histidinemia | A | Can lead a claim |
| E7049 | Other disorders of histidine metabolism | A | Can lead a claim |
| E705 | Disorders of tryptophan metabolism | A | Can lead a claim |
| E7081 | Aromatic L-amino acid decarboxylase deficiency | A | Can lead a claim |
| E7089 | Other disorders of aromatic amino-acid metabolism | A | Can lead a claim |
| E709 | Disorder of aromatic amino-acid metabolism, unspecified | A | Can lead a claim |
| E710 | Maple-syrup-urine disease | A | Can lead a claim |
| E71110 | Isovaleric acidemia | A | Can lead a claim |
| E71111 | 3-methylglutaconic aciduria | A | Can lead a claim |
| E71118 | Other branched-chain organic acidurias | A | Can lead a claim |
| E71120 | Methylmalonic acidemia | A | Can lead a claim |
| E71121 | Propionic acidemia | A | Can lead a claim |
| E71128 | Other disorders of propionate metabolism | A | Can lead a claim |
| E7119 | Other disorders of branched-chain amino-acid metabolism | A | Can lead a claim |
| E712 | Disorder of branched-chain amino-acid metabolism, unsp | A | Can lead a claim |
| E7130 | Disorder of fatty-acid metabolism, unspecified | A | Can lead a claim |
| E71310 | Long chain/very long chain acyl CoA dehydrogenase deficiency | A | Can lead a claim |
| E71311 | Medium chain acyl CoA dehydrogenase deficiency | A | Can lead a claim |
| E71312 | Short chain acyl CoA dehydrogenase deficiency | A | Can lead a claim |
| E71313 | Glutaric aciduria type II | A | Can lead a claim |
| E71314 | Muscle carnitine palmitoyltransferase deficiency | A | Can lead a claim |
| E71318 | Other disorders of fatty-acid oxidation | A | Can lead a claim |
| E7132 | Disorders of ketone metabolism | A | Can lead a claim |
| E7139 | Other disorders of fatty-acid metabolism | A | Can lead a claim |
| E7140 | Disorder of carnitine metabolism, unspecified | A | Can lead a claim |
| E7141 | Primary carnitine deficiency | A | Can lead a claim |
| E7142 | Carnitine deficiency due to inborn errors of metabolism | A | Can lead a claim |
| E7143 | Iatrogenic carnitine deficiency | A | Can lead a claim |
| E71440 | Ruvalcaba-Myhre-Smith syndrome | A | Can lead a claim |
| E71448 | Other secondary carnitine deficiency | A | Can lead a claim |
| E7150 | Peroxisomal disorder, unspecified | A | Can lead a claim |
| E71510 | Zellweger syndrome | A | Can lead a claim |
| E71511 | Neonatal adrenoleukodystrophy | A | Can lead a claim |
| E71518 | Other disorders of peroxisome biogenesis | A | Can lead a claim |
| E71520 | Childhood cerebral X-linked adrenoleukodystrophy | A | Can lead a claim |
| E71521 | Adolescent X-linked adrenoleukodystrophy | A | Can lead a claim |
| E71522 | Adrenomyeloneuropathy | A | Can lead a claim |
| E71528 | Other X-linked adrenoleukodystrophy | A | Can lead a claim |
| E71529 | X-linked adrenoleukodystrophy, unspecified type | A | Can lead a claim |
| E7153 | Other group 2 peroxisomal disorders | A | Can lead a claim |
| E71540 | Rhizomelic chondrodysplasia punctata | A | Can lead a claim |
| E71541 | Zellweger-like syndrome | A | Can lead a claim |
| E71542 | Other group 3 peroxisomal disorders | A | Can lead a claim |
| E71548 | Other peroxisomal disorders | A | Can lead a claim |
| E7200 | Disorders of amino-acid transport, unspecified | A | Can lead a claim |
| E7201 | Cystinuria | A | Can lead a claim |
| E7202 | Hartnup's disease | A | Can lead a claim |
| E7203 | Lowe's syndrome | A | Can lead a claim |
| E7204 | Cystinosis | A | Can lead a claim |
| E7209 | Other disorders of amino-acid transport | A | Can lead a claim |
| E7210 | Disorders of sulfur-bearing amino-acid metabolism, unsp | A | Can lead a claim |
| E7211 | Homocystinuria | A | Can lead a claim |
| E7212 | Methylenetetrahydrofolate reductase deficiency | A | Can lead a claim |
| E7219 | Other disorders of sulfur-bearing amino-acid metabolism | A | Can lead a claim |
| E7220 | Disorder of urea cycle metabolism, unspecified | A | Can lead a claim |
| E7221 | Argininemia | A | Can lead a claim |
| E7222 | Arginosuccinic aciduria | A | Can lead a claim |
| E7223 | Citrullinemia | A | Can lead a claim |
| E7229 | Other disorders of urea cycle metabolism | A | Can lead a claim |
| E723 | Disorders of lysine and hydroxylysine metabolism | A | Can lead a claim |
| E724 | Disorders of ornithine metabolism | A | Can lead a claim |
| E7250 | Disorder of glycine metabolism, unspecified | A | Can lead a claim |
| E7251 | Non-ketotic hyperglycinemia | A | Can lead a claim |
| E7252 | Trimethylaminuria | A | Can lead a claim |
| E72530 | Primary hyperoxaluria, type 1 | A | Can lead a claim |
| E72538 | Other specified primary hyperoxaluria | A | Can lead a claim |
| E72539 | Primary hyperoxaluria, unspecified | A | Can lead a claim |
| E72540 | Dietary hyperoxaluria | A | Can lead a claim |
| E72541 | Enteric hyperoxaluria | A | Can lead a claim |
| E72548 | Other secondary hyperoxaluria | A | Can lead a claim |
| E72549 | Secondary hyperoxaluria, unspecified | A | Can lead a claim |
| E7259 | Other disorders of glycine metabolism | A | Can lead a claim |
| E7281 | Disorders of gamma aminobutyric acid metabolism | I | Can lead a claim |
| E7289 | Other specified disorders of amino-acid metabolism | I | Can lead a claim |
| E729 | Disorder of amino-acid metabolism, unspecified | None | Cannot lead a claim |
| E730 | Congenital lactase deficiency | A | Can lead a claim |
| E731 | Secondary lactase deficiency | A | Can lead a claim |
| E738 | Other lactose intolerance | A | Can lead a claim |
| E739 | Lactose intolerance, unspecified | A | Can lead a claim |
| E7400 | Glycogen storage disease, unspecified | A | Can lead a claim |
| E7401 | von Gierke disease | A | Can lead a claim |
| E7402 | Pompe disease | A | Can lead a claim |
| E7403 | Cori disease | A | Can lead a claim |
| E7404 | McArdle disease | A | Can lead a claim |
| E7405 | Lysosome-associated membrane protein 2 [LAMP2] deficiency | A | Can lead a claim |
| E7409 | Other glycogen storage disease | A | Can lead a claim |
| E7410 | Disorder of fructose metabolism, unspecified | A | Can lead a claim |
| E7411 | Essential fructosuria | A | Can lead a claim |
| E7412 | Hereditary fructose intolerance | A | Can lead a claim |
| E7419 | Other disorders of fructose metabolism | A | Can lead a claim |
| E7420 | Disorders of galactose metabolism, unspecified | A | Can lead a claim |
| E7421 | Galactosemia | A | Can lead a claim |
| E7429 | Other disorders of galactose metabolism | A | Can lead a claim |
| E7431 | Sucrase-isomaltase deficiency | A | Can lead a claim |
| E7439 | Other disorders of intestinal carbohydrate absorption | A | Can lead a claim |
| E744 | Disorders of pyruvate metabolism and gluconeogenesis | A | Can lead a claim |
| E74810 | Glucose transporter protein type 1 deficiency | A | Can lead a claim |
| E74818 | Other disorders of glucose transport | A | Can lead a claim |
| E74819 | Disorders of glucose transport, unspecified | A | Can lead a claim |
| E74820 | SLC13A5 Citrate Transporter Disorder | A | Can lead a claim |
| E74829 | Other disorders of citrate metabolism | A | Can lead a claim |
| E7489 | Other specified disorders of carbohydrate metabolism | A | Can lead a claim |
| E749 | Disorder of carbohydrate metabolism, unspecified | None | Cannot lead a claim |
| E7500 | GM2 gangliosidosis, unspecified | A | Can lead a claim |
| E7501 | Sandhoff disease | A | Can lead a claim |
| E7502 | Tay-Sachs disease | A | Can lead a claim |
| E7509 | Other GM2 gangliosidosis | A | Can lead a claim |
| E7510 | Unspecified gangliosidosis | A | Can lead a claim |
| E7511 | Mucolipidosis IV | A | Can lead a claim |
| E7519 | Other gangliosidosis | A | Can lead a claim |
| E7521 | Fabry (-Anderson) disease | A | Can lead a claim |
| E7522 | Gaucher disease | A | Can lead a claim |
| E7523 | Krabbe disease | A | Can lead a claim |
| E75240 | Niemann-Pick disease type A | A | Can lead a claim |
| E75241 | Niemann-Pick disease type B | A | Can lead a claim |
| E75242 | Niemann-Pick disease type C | A | Can lead a claim |
| E75243 | Niemann-Pick disease type D | A | Can lead a claim |
| E75244 | Niemann-Pick disease type A/B | K | Can lead a claim |
| E75248 | Other Niemann-Pick disease | A | Can lead a claim |
| E75249 | Niemann-Pick disease, unspecified | A | Can lead a claim |
| E7525 | Metachromatic leukodystrophy | A | Can lead a claim |
| E7526 | Sulfatase deficiency | B | Can lead a claim |
| E7527 | Pelizaeus-Merzbacher disease | A | Can lead a claim |
| E7528 | Canavan disease | A | Can lead a claim |
| E7529 | Other sphingolipidosis | A | Can lead a claim |
| E753 | Sphingolipidosis, unspecified | A | Can lead a claim |
| E754 | Neuronal ceroid lipofuscinosis | A | Can lead a claim |
| E755 | Other lipid storage disorders | A | Can lead a claim |
| E756 | Lipid storage disorder, unspecified | A | Can lead a claim |
| E7601 | Hurler's syndrome | A | Can lead a claim |
| E7602 | Hurler-Scheie syndrome | A | Can lead a claim |
| E7603 | Scheie's syndrome | A | Can lead a claim |
| E761 | Mucopolysaccharidosis, type II | A | Can lead a claim |
| E76210 | Morquio A mucopolysaccharidoses | A | Can lead a claim |
| E76211 | Morquio B mucopolysaccharidoses | A | Can lead a claim |
| E76219 | Morquio mucopolysaccharidoses, unspecified | A | Can lead a claim |
| E7622 | Sanfilippo mucopolysaccharidoses | A | Can lead a claim |
| E7629 | Other mucopolysaccharidoses | A | Can lead a claim |
| E763 | Mucopolysaccharidosis, unspecified | A | Can lead a claim |
| E768 | Other disorders of glucosaminoglycan metabolism | A | Can lead a claim |
| E769 | Glucosaminoglycan metabolism disorder, unspecified | A | Can lead a claim |
| E770 | Defects in post-translational mod of lysosomal enzymes | A | Can lead a claim |
| E771 | Defects in glycoprotein degradation | A | Can lead a claim |
| E778 | Other disorders of glycoprotein metabolism | A | Can lead a claim |
| E779 | Disorder of glycoprotein metabolism, unspecified | A | Can lead a claim |
| E7800 | Pure hypercholesterolemia, unspecified | A | Can lead a claim |
| E78010 | Homozygous familial hypercholesterolemia [HoFH] | A | Can lead a claim |
| E78011 | Heterozygous familial hypercholesterolemia [HeFH] | A | Can lead a claim |
| E78019 | Familial hypercholesterolemia, unspecified | A | Can lead a claim |
| E781 | Pure hyperglyceridemia | A | Can lead a claim |
| E782 | Mixed hyperlipidemia | A | Can lead a claim |
| E783 | Hyperchylomicronemia | A | Can lead a claim |
| E7841 | Elevated Lipoprotein(a) | A | Can lead a claim |
| E7849 | Other hyperlipidemia | A | Can lead a claim |
| E785 | Hyperlipidemia, unspecified | A | Can lead a claim |
| E786 | Lipoprotein deficiency | A | Can lead a claim |
| E7870 | Disorder of bile acid and cholesterol metabolism, unsp | A | Can lead a claim |
| E7871 | Barth syndrome | A | Can lead a claim |
| E7872 | Smith-Lemli-Opitz syndrome | A | Can lead a claim |
| E7879 | Other disorders of bile acid and cholesterol metabolism | A | Can lead a claim |
| E7881 | Lipoid dermatoarthritis | A | Can lead a claim |
| E7889 | Other lipoprotein metabolism disorders | A | Can lead a claim |
| E789 | Disorder of lipoprotein metabolism, unspecified | None | Cannot lead a claim |
| E790 | Hyperuricemia w/o signs of inflam arthrit and tophaceous dis | A | Can lead a claim |
| E791 | Lesch-Nyhan syndrome | A | Can lead a claim |
| E792 | Myoadenylate deaminase deficiency | A | Can lead a claim |
| E7981 | Aicardi-Goutieres syndrome | A | Can lead a claim |
| E7982 | Hereditary xanthinuria | A | Can lead a claim |
| E7989 | Oth disrd of purine and pyrimidine metabolism | None | Cannot lead a claim |
| E799 | Disorder of purine and pyrimidine metabolism, unspecified | A | Can lead a claim |
| E800 | Hereditary erythropoietic porphyria | A | Can lead a claim |
| E801 | Porphyria cutanea tarda | A | Can lead a claim |
| E8020 | Unspecified porphyria | A | Can lead a claim |
| E8021 | Acute intermittent (hepatic) porphyria | A | Can lead a claim |
| E8029 | Other porphyria | A | Can lead a claim |
| E803 | Defects of catalase and peroxidase | A | Can lead a claim |
| E804 | Gilbert syndrome | A | Can lead a claim |
| E805 | Crigler-Najjar syndrome | A | Can lead a claim |
| E806 | Other disorders of bilirubin metabolism | A | Can lead a claim |
| E807 | Disorder of bilirubin metabolism, unspecified | A | Can lead a claim |
| E8300 | Disorder of copper metabolism, unspecified | A | Can lead a claim |
| E8301 | Wilson's disease | A | Can lead a claim |
| E8309 | Other disorders of copper metabolism | A | Can lead a claim |
| E8310 | Disorder of iron metabolism, unspecified | A | Can lead a claim |
| E83110 | Hereditary hemochromatosis | A | Can lead a claim |
| E83111 | Hemochromatosis due to repeated red blood cell transfusions | A | Can lead a claim |
| E83118 | Other hemochromatosis | A | Can lead a claim |
| E83119 | Hemochromatosis, unspecified | A | Can lead a claim |
| E8319 | Other disorders of iron metabolism | A | Can lead a claim |
| E832 | Disorders of zinc metabolism | A | Can lead a claim |
| E8330 | Disorder of phosphorus metabolism, unspecified | A | Can lead a claim |
| E8331 | Familial hypophosphatemia | A | Can lead a claim |
| E8332 | Hereditary vitamin D-dependent rickets (type 1) (type 2) | A | Can lead a claim |
| E8339 | Other disorders of phosphorus metabolism | A | Can lead a claim |
| E8340 | Disorders of magnesium metabolism, unspecified | A | Can lead a claim |
| E8341 | Hypermagnesemia | A | Can lead a claim |
| E8342 | Hypomagnesemia | A | Can lead a claim |
| E8349 | Other disorders of magnesium metabolism | A | Can lead a claim |
| E8350 | Unspecified disorder of calcium metabolism | A | Can lead a claim |
| E8351 | Hypocalcemia | A | Can lead a claim |
| E8352 | Hypercalcemia | A | Can lead a claim |
| E8359 | Other disorders of calcium metabolism | A | Can lead a claim |
| E8381 | Hungry bone syndrome | A | Can lead a claim |
| E83820 | Gen arterial calcifcn of infancy with unsp genetic causality | A | Can lead a claim |
| E83821 | ENPP1 deficiency causing gen arterial calcifcn of infancy | A | Can lead a claim |
| E83822 | ENPP1 def cause autosom recess hypophosphate rickets type 2 | A | Can lead a claim |
| E83823 | ABCC6 deficiency causing gen arterial calcifcn of infancy | A | Can lead a claim |
| E83824 | ABCC6 deficiency causing pseudoxanthoma elasticum | A | Can lead a claim |
| E83825 | CD73 deficiency causing arterial calcification | A | Can lead a claim |
| E8389 | Other disorders of mineral metabolism | A | Can lead a claim |
| E839 | Disorder of mineral metabolism, unspecified | None | Cannot lead a claim |
| E840 | Cystic fibrosis with pulmonary manifestations | I | Can lead a claim |
| E8411 | Meconium ileus in cystic fibrosis | A | Can lead a claim |
| E8419 | Cystic fibrosis with other intestinal manifestations | I | Can lead a claim |
| E848 | Cystic fibrosis with other manifestations | I | Can lead a claim |
| E849 | Cystic fibrosis, unspecified | I | Can lead a claim |
| E850 | Non-neuropathic heredofamilial amyloidosis | I | Can lead a claim |
| E851 | Neuropathic heredofamilial amyloidosis | I | Can lead a claim |
| E852 | Heredofamilial amyloidosis, unspecified | I | Can lead a claim |
| E853 | Secondary systemic amyloidosis | I | Can lead a claim |
| E854 | Organ-limited amyloidosis | I | Can lead a claim |
| E8581 | Light chain (AL) amyloidosis | I | Can lead a claim |
| E8582 | Wild-type transthyretin-related (ATTR) amyloidosis | I | Can lead a claim |
| E8589 | Other amyloidosis | I | Can lead a claim |
| E859 | Amyloidosis, unspecified | I | Can lead a claim |
| E860 | Dehydration | A | Can lead a claim |
| E861 | Hypovolemia | A | Can lead a claim |
| E869 | Volume depletion, unspecified | A | Can lead a claim |
| E870 | Hyperosmolality and hypernatremia | A | Can lead a claim |
| E871 | Hypo-osmolality and hyponatremia | A | Can lead a claim |
| E8720 | Acidosis, unspecified | A | Can lead a claim |
| E8721 | Acute metabolic acidosis | A | Can lead a claim |
| E8722 | Chronic metabolic acidosis | A | Can lead a claim, code first applies |
| E8729 | Other acidosis | A | Can lead a claim |
| E873 | Alkalosis | A | Can lead a claim |
| E874 | Mixed disorder of acid-base balance | A | Can lead a claim |
| E875 | Hyperkalemia | A | Can lead a claim |
| E876 | Hypokalemia | A | Can lead a claim |
| E8770 | Fluid overload, unspecified | A | Can lead a claim |
| E8771 | Transfusion associated circulatory overload | A | Can lead a claim |
| E8779 | Other fluid overload | A | Can lead a claim |
| E878 | Oth disorders of electrolyte and fluid balance, NEC | A | Can lead a claim |
| E8801 | Alpha-1-antitrypsin deficiency | A | Can lead a claim |
| E8802 | Plasminogen deficiency | A | Can lead a claim |
| E8809 | Oth disorders of plasma-protein metabolism, NEC | A | Can lead a claim |
| E8810 | Lipodystrophy, unspecified | A | Can lead a claim |
| E8811 | Partial lipodystrophy | A | Can lead a claim |
| E8812 | Generalized lipodystrophy | A | Can lead a claim |
| E8813 | Localized lipodystrophy | A | Can lead a claim |
| E8814 | HIV-associated lipodystrophy | A | Can lead a claim, code first applies |
| E8819 | Other lipodystrophy, not elsewhere classified | A | Can lead a claim |
| E882 | Lipomatosis, not elsewhere classified | A | Can lead a claim |
| E883 | Tumor lysis syndrome | A | Can lead a claim |
| E8840 | Mitochondrial metabolism disorder, unspecified | A | Can lead a claim |
| E8841 | MELAS syndrome | A | Can lead a claim |
| E8842 | MERRF syndrome | A | Can lead a claim |
| E8843 | Disorders of mitochondrial tRNA synthetases | A | Can lead a claim |
| E8849 | Other mitochondrial metabolism disorders | A | Can lead a claim |
| E88810 | Metabolic syndrome | A | Can lead a claim |
| E88811 | Insulin resistance syndrome, Type A | A | Can lead a claim |
| E88818 | Other insulin resistance | A | Can lead a claim |
| E88819 | Insulin resistance, unspecified | A | Can lead a claim |
| E8882 | Obesity due to disruption of MC4R pathway | A | Can lead a claim |
| E8889 | Other specified metabolic disorders | A | Can lead a claim |
| E889 | Metabolic disorder, unspecified | None | Cannot lead a claim |
| E88A | Wasting disease (syndrome) due to underlying condition | None | Cannot lead a claim |
Source: CMS HH PPS Grouper Software v07.2.26, effective 2026-10-01. This is the crosswalk Medicare runs a claim through. Grouping also depends on admission source, timing, the OASIS functional items and the rest of the diagnosis list.
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