ICD-10 · PDGM grouping
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
All 26 codes in the E75 family, with the PDGM clinical group, comorbidity subgroup and primary-position rule CMS assigns, read from the CMS grouper crosswalk v07.2.26 and the CDC FY2027 code file.
Codes in family
26
Can lead a claim
26
Cannot lead a claim
0
What CMS assigns to E75
All 26 codes group to MMTA - Other (24), Neuro Rehabilitation (1) and MMTA - Infectious Disease, Neoplasms, and Blood-Forming Diseases (1). 2 of the 26 count toward the Demyelinating Diseases of the Central Nervous System comorbidity subgroup; 24 are assigned none. Every code can lead a claim.
- AMMTA - Other24
- BNeuro Rehabilitation1
- KMMTA - Infectious Disease, Neoplasms, and Blood-Forming Diseases1
- Demyelinating Diseases of the Central Nervous System
Every code in E75
Descriptions are CDC’s FY2027 wording; where CMS’s grouper abbreviates one, its form is shown beneath.
| Code | Description | Primary position | Clinical group | Comorbidity subgroup |
|---|---|---|---|---|
| E75.0 GM2 gangliosidosis | ||||
| E75.00 | GM2 gangliosidosis, unspecified | Can lead a claim | A | None |
| E75.01 | Sandhoff disease | Can lead a claim | A | None |
| E75.02 | Tay-Sachs disease | Can lead a claim | A | None |
| E75.09 | Other GM2 gangliosidosis | Can lead a claim | A | None |
| E75.1 Other and unspecified gangliosidosis | ||||
| E75.10 | Unspecified gangliosidosis | Can lead a claim | A | None |
| E75.11 | Mucolipidosis IV | Can lead a claim | A | None |
| E75.19 | Other gangliosidosis | Can lead a claim | A | None |
| E75.2 Other sphingolipidosis | ||||
| E75.21 | Fabry (-Anderson) disease | Can lead a claim | A | None |
| E75.22 | Gaucher disease | Can lead a claim | A | None |
| E75.23 | Krabbe disease | Can lead a claim | A | None |
| E75.24 Niemann-Pick disease | ||||
| E75.240 | Niemann-Pick disease type A | Can lead a claim | A | None |
| E75.241 | Niemann-Pick disease type B | Can lead a claim | A | None |
| E75.242 | Niemann-Pick disease type C | Can lead a claim | A | None |
| E75.243 | Niemann-Pick disease type D | Can lead a claim | A | None |
| E75.244 | Niemann-Pick disease type A/B | Can lead a claim | K | None |
| E75.248 | Other Niemann-Pick disease | Can lead a claim | A | None |
| E75.249 | Niemann-Pick disease, unspecified | Can lead a claim | A | None |
| E75.25 | Metachromatic leukodystrophy | Can lead a claim | A | None |
| E75.26 | Sulfatase deficiency | Can lead a claim | B | None |
| E75.27 | Pelizaeus-Merzbacher disease | Can lead a claim | A | Demyelinating Diseases of the Central Nervous System |
| E75.28 | Canavan disease | Can lead a claim | A | Demyelinating Diseases of the Central Nervous System |
| E75.29 | Other sphingolipidosis | Can lead a claim | A | None |
| E75.3 | Sphingolipidosis, unspecified | Can lead a claim | A | None |
| E75.4 | Neuronal ceroid lipofuscinosis | Can lead a claim | A | None |
| E75.5 | Other lipid storage disorders | Can lead a claim | A | None |
| E75.6 | Lipid storage disorder, unspecified | Can lead a claim | A | None |
Sources: CMS HH PPS Grouper Software v07.2.26, effective 2026-10-01, for the clinical group, comorbidity subgroup, code-first conventions and primary-position flags; CDC NCHS ICD-10-CM FY2027 code descriptions for the family title and code wording. This is the crosswalk Medicare runs a claim through. Grouping also depends on admission source, timing, the OASIS functional items and the rest of the diagnosis list.
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