October 1 update. Our PDGM and ICD-10 tools now use the FY2027 code set: 190 codes added, 30 deleted, and no existing code changed clinical group.

See what changed

ICD-10 · PDGM grouping

E85 Amyloidosis

All 9 codes in the E85 family, with the PDGM clinical group, comorbidity subgroup and primary-position rule CMS assigns, read from the CMS grouper crosswalk v07.2.26 and the CDC FY2027 code file.

ICD-10-CM FY2027 · CMS grouper v07.2.26

Codes in family

9

Can lead a claim

9

Cannot lead a claim

0

What CMS assigns to E85

All 9 codes group to MMTA - Endocrine. None of the 9 is assigned a comorbidity subgroup. Every code can lead a claim.

Every code in E85

Descriptions are CDC’s FY2027 wording; where CMS’s grouper abbreviates one, its form is shown beneath.

CodeDescriptionPrimary positionClinical groupComorbidity subgroup
E85.0Non-neuropathic heredofamilial amyloidosisCan lead a claimINone
E85.1Neuropathic heredofamilial amyloidosisCan lead a claimINone
E85.2Heredofamilial amyloidosis, unspecifiedCan lead a claimINone
E85.3Secondary systemic amyloidosisCan lead a claimINone
E85.4Organ-limited amyloidosisCan lead a claimINone
E85.8 Other amyloidosis
E85.81Light chain (AL) amyloidosisCan lead a claimINone
E85.82Wild-type transthyretin-related (ATTR) amyloidosisCan lead a claimINone
E85.89Other amyloidosisCan lead a claimINone
E85.9Amyloidosis, unspecifiedCan lead a claimINone

Sources: CMS HH PPS Grouper Software v07.2.26, effective 2026-10-01, for the clinical group, comorbidity subgroup, code-first conventions and primary-position flags; CDC NCHS ICD-10-CM FY2027 code descriptions for the family title and code wording. This is the crosswalk Medicare runs a claim through. Grouping also depends on admission source, timing, the OASIS functional items and the rest of the diagnosis list.

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