ICD-10 · PDGM grouping
E72 Other disorders of amino-acid metabolism
All 31 codes in the E72 family, with the PDGM clinical group, comorbidity subgroup and primary-position rule CMS assigns, read from the CMS grouper crosswalk v07.2.26 and the CDC FY2027 code file.
Codes in family
31
Can lead a claim
30
Cannot lead a claim
1
What CMS assigns to E72
30 of the 31 codes group to MMTA - Other (28) and MMTA - Endocrine (2); 1 is assigned no clinical group. None of the 31 is assigned a comorbidity subgroup. 30 of the 31 can lead a claim.
Every code in E72
Descriptions are CDC’s FY2027 wording; where CMS’s grouper abbreviates one, its form is shown beneath.
| Code | Description | Primary position | Clinical group | Comorbidity subgroup |
|---|---|---|---|---|
| E72.0 Disorders of amino-acid transport | ||||
| E72.00 | Disorders of amino-acid transport, unspecified | Can lead a claim | A | None |
| E72.01 | Cystinuria | Can lead a claim | A | None |
| E72.02 | Hartnup's disease | Can lead a claim | A | None |
| E72.03 | Lowe's syndrome | Can lead a claim | A | None |
| E72.04 | Cystinosis | Can lead a claim | A | None |
| E72.09 | Other disorders of amino-acid transport | Can lead a claim | A | None |
| E72.1 Disorders of sulfur-bearing amino-acid metabolism | ||||
| E72.10 | Disorders of sulfur-bearing amino-acid metabolism, unspecifiedCMS: Disorders of sulfur-bearing amino-acid metabolism, unsp | Can lead a claim | A | None |
| E72.11 | Homocystinuria | Can lead a claim | A | None |
| E72.12 | Methylenetetrahydrofolate reductase deficiency | Can lead a claim | A | None |
| E72.19 | Other disorders of sulfur-bearing amino-acid metabolism | Can lead a claim | A | None |
| E72.2 Disorders of urea cycle metabolism | ||||
| E72.20 | Disorder of urea cycle metabolism, unspecified | Can lead a claim | A | None |
| E72.21 | Argininemia | Can lead a claim | A | None |
| E72.22 | Arginosuccinic aciduria | Can lead a claim | A | None |
| E72.23 | Citrullinemia | Can lead a claim | A | None |
| E72.29 | Other disorders of urea cycle metabolism | Can lead a claim | A | None |
| E72.3 | Disorders of lysine and hydroxylysine metabolism | Can lead a claim | A | None |
| E72.4 | Disorders of ornithine metabolism | Can lead a claim | A | None |
| E72.5 Disorders of glycine metabolism | ||||
| E72.50 | Disorder of glycine metabolism, unspecified | Can lead a claim | A | None |
| E72.51 | Non-ketotic hyperglycinemia | Can lead a claim | A | None |
| E72.52 | Trimethylaminuria | Can lead a claim | A | None |
| E72.53 Primary hyperoxaluria | ||||
| E72.530 | Primary hyperoxaluria, type 1 | Can lead a claim | A | None |
| E72.538 | Other specified primary hyperoxaluria | Can lead a claim | A | None |
| E72.539 | Primary hyperoxaluria, unspecified | Can lead a claim | A | None |
| E72.54 Secondary hyperoxaluria | ||||
| E72.540 | Dietary hyperoxaluria | Can lead a claim | A | None |
| E72.541 | Enteric hyperoxaluria | Can lead a claim | A | None |
| E72.548 | Other secondary hyperoxaluria | Can lead a claim | A | None |
| E72.549 | Secondary hyperoxaluria, unspecified | Can lead a claim | A | None |
| E72.59 | Other disorders of glycine metabolism | Can lead a claim | A | None |
| E72.8 Other specified disorders of amino-acid metabolism | ||||
| E72.81 | Disorders of gamma aminobutyric acid metabolism | Can lead a claim | I | None |
| E72.89 | Other specified disorders of amino-acid metabolism | Can lead a claim | I | None |
| E72.9 | Disorder of amino-acid metabolism, unspecified | Cannot lead a claimPrincipal diagnosis not assigned to a clinical group | None | None |
Sources: CMS HH PPS Grouper Software v07.2.26, effective 2026-10-01, for the clinical group, comorbidity subgroup, code-first conventions and primary-position flags; CDC NCHS ICD-10-CM FY2027 code descriptions for the family title and code wording. This is the crosswalk Medicare runs a claim through. Grouping also depends on admission source, timing, the OASIS functional items and the rest of the diagnosis list.
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