ICD-10 · PDGM grouping
Z16 Resistance to antimicrobial drugs
All 19 codes in the Z16 family, with the PDGM clinical group, comorbidity subgroup and primary-position rule CMS assigns, read from the CMS grouper crosswalk v07.2.26 and the CDC FY2027 code file.
Codes in family
19
Can lead a claim
0
Cannot lead a claim
19
What CMS assigns to Z16
None of the 19 codes is assigned a clinical group. None of the 19 is assigned a comorbidity subgroup. None can lead a claim. CMS attaches a code-first note to all 19.
Code first
CMS grouper convention 12, on all 19 codes. Code first:
- underlying disease
Every code in Z16
Descriptions are CDC’s FY2027 wording; where CMS’s grouper abbreviates one, its form is shown beneath.
| Code | Description | Primary position | Clinical group | Comorbidity subgroup |
|---|---|---|---|---|
| Z16.1 Resistance to beta lactam antibiotics | ||||
| Z16.10 | Resistance to unspecified beta lactam antibiotics | Cannot lead a claimUnacceptable principal diagnosis, code is not reportable as principal diagnosis | None | None |
| Z16.11 | Resistance to penicillins | Cannot lead a claimUnacceptable principal diagnosis, code is not reportable as principal diagnosis | None | None |
| Z16.12 | Extended spectrum beta lactamase (ESBL) resistance | Cannot lead a claimUnacceptable principal diagnosis, code is not reportable as principal diagnosis | None | None |
| Z16.13 | Resistance to carbapenem | Cannot lead a claimUnacceptable principal diagnosis, code is not reportable as principal diagnosis | None | None |
| Z16.19 | Resistance to other specified beta lactam antibiotics | Cannot lead a claimUnacceptable principal diagnosis, code is not reportable as principal diagnosis | None | None |
| Z16.2 Resistance to other antibiotics | ||||
| Z16.20 | Resistance to unspecified antibiotic | Cannot lead a claimUnacceptable principal diagnosis, code is not reportable as principal diagnosis | None | None |
| Z16.21 | Resistance to vancomycin | Cannot lead a claimUnacceptable principal diagnosis, code is not reportable as principal diagnosis | None | None |
| Z16.22 | Resistance to vancomycin related antibiotics | Cannot lead a claimUnacceptable principal diagnosis, code is not reportable as principal diagnosis | None | None |
| Z16.23 | Resistance to quinolones and fluoroquinolones | Cannot lead a claimUnacceptable principal diagnosis, code is not reportable as principal diagnosis | None | None |
| Z16.24 | Resistance to multiple antibiotics | Cannot lead a claimUnacceptable principal diagnosis, code is not reportable as principal diagnosis | None | None |
| Z16.29 | Resistance to other single specified antibiotic | Cannot lead a claimUnacceptable principal diagnosis, code is not reportable as principal diagnosis | None | None |
| Z16.3 Resistance to other antimicrobial drugs | ||||
| Z16.30 | Resistance to unspecified antimicrobial drugs | Cannot lead a claimUnacceptable principal diagnosis, code is not reportable as principal diagnosis | None | None |
| Z16.31 | Resistance to antiparasitic drug(s) | Cannot lead a claimUnacceptable principal diagnosis, code is not reportable as principal diagnosis | None | None |
| Z16.32 | Resistance to antifungal drug(s) | Cannot lead a claimUnacceptable principal diagnosis, code is not reportable as principal diagnosis | None | None |
| Z16.33 | Resistance to antiviral drug(s) | Cannot lead a claimUnacceptable principal diagnosis, code is not reportable as principal diagnosis | None | None |
| Z16.34 Resistance to antimycobacterial drug(s) | ||||
| Z16.341 | Resistance to single antimycobacterial drug | Cannot lead a claimUnacceptable principal diagnosis, code is not reportable as principal diagnosis | None | None |
| Z16.342 | Resistance to multiple antimycobacterial drugs | Cannot lead a claimUnacceptable principal diagnosis, code is not reportable as principal diagnosis | None | None |
| Z16.35 | Resistance to multiple antimicrobial drugs | Cannot lead a claimUnacceptable principal diagnosis, code is not reportable as principal diagnosis | None | None |
| Z16.39 | Resistance to other specified antimicrobial drug | Cannot lead a claimUnacceptable principal diagnosis, code is not reportable as principal diagnosis | None | None |
Sources: CMS HH PPS Grouper Software v07.2.26, effective 2026-10-01, for the clinical group, comorbidity subgroup, code-first conventions and primary-position flags; CDC NCHS ICD-10-CM FY2027 code descriptions for the family title and code wording. This is the crosswalk Medicare runs a claim through. Grouping also depends on admission source, timing, the OASIS functional items and the rest of the diagnosis list.
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