October 1 update. Our PDGM and ICD-10 tools now use the FY2027 code set: 190 codes added, 30 deleted, and no existing code changed clinical group.

See what changed

ICD-10 · PDGM grouping

Z16-Z16 — Resistance to antimicrobial drugs

Every ICD-10-CM code in this range and the PDGM clinical group CMS assigns to it, read from the CMS grouper crosswalk v07.2.26.

ICD-10-CM FY2027 · CMS grouper v07.2.26

Codes in range

19

No clinical group

19

A period cannot be grouped from these.

Barred as primary

19

CMS rejects these in the primary position.

Where these codes group

None of the 19 codes in Z16-Z16 is assigned a PDGM clinical group. A 30-day period cannot be grouped from any of them, so none can hold the primary position on a home health claim.

Code families in Z16-Z16

One page per three-character family: every code in it, whether it can lead a claim, its clinical group and comorbidity subgroup.

Every code in Z16-Z16

Descriptions are CMS’s own, abbreviated as CMS abbreviates them.

CodeDescriptionClinical groupPrimary position
Z1610Resistance to unspecified beta lactam antibioticsNoneCannot lead a claim
Z1611Resistance to penicillinsNoneCannot lead a claim
Z1612Extended spectrum beta lactamase (ESBL) resistanceNoneCannot lead a claim
Z1613Resistance to carbapenemNoneCannot lead a claim
Z1619Resistance to other specified beta lactam antibioticsNoneCannot lead a claim
Z1620Resistance to unspecified antibioticNoneCannot lead a claim
Z1621Resistance to vancomycinNoneCannot lead a claim
Z1622Resistance to vancomycin related antibioticsNoneCannot lead a claim
Z1623Resistance to quinolones and fluoroquinolonesNoneCannot lead a claim
Z1624Resistance to multiple antibioticsNoneCannot lead a claim
Z1629Resistance to other single specified antibioticNoneCannot lead a claim
Z1630Resistance to unspecified antimicrobial drugsNoneCannot lead a claim
Z1631Resistance to antiparasitic drug(s)NoneCannot lead a claim
Z1632Resistance to antifungal drug(s)NoneCannot lead a claim
Z1633Resistance to antiviral drug(s)NoneCannot lead a claim
Z16341Resistance to single antimycobacterial drugNoneCannot lead a claim
Z16342Resistance to multiple antimycobacterial drugsNoneCannot lead a claim
Z1635Resistance to multiple antimicrobial drugsNoneCannot lead a claim
Z1639Resistance to other specified antimicrobial drugNoneCannot lead a claim

Source: CMS HH PPS Grouper Software v07.2.26, effective 2026-10-01. This is the crosswalk Medicare runs a claim through. Grouping also depends on admission source, timing, the OASIS functional items and the rest of the diagnosis list.

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