ICD-10 · PDGM grouping
Z17 Estrogen, and other hormones and factors receptor status
All 10 codes in the Z17 family, with the PDGM clinical group, comorbidity subgroup and primary-position rule CMS assigns, read from the CMS grouper crosswalk v07.2.26 and the CDC FY2027 code file.
Codes in family
10
Can lead a claim
0
Cannot lead a claim
10
What CMS assigns to Z17
None of the 10 codes is assigned a clinical group. None of the 10 is assigned a comorbidity subgroup. None can lead a claim. CMS attaches a code-first note to all 10.
Code first
CMS grouper convention 174, on all 10 codes. Code first:
- malignant neoplasm of breast (C50.-)
- malignant neoplasm of ovary (C56.-)
- malignant neoplasm, such as:
Every code in Z17
Descriptions are CDC’s FY2027 wording; where CMS’s grouper abbreviates one, its form is shown beneath.
| Code | Description | Primary position | Clinical group | Comorbidity subgroup |
|---|---|---|---|---|
| Z17.0 | Estrogen receptor positive status [ER+] | Cannot lead a claimUnacceptable principal diagnosis, code is not reportable as principal diagnosis | None | None |
| Z17.1 | Estrogen receptor negative status [ER-] | Cannot lead a claimUnacceptable principal diagnosis, code is not reportable as principal diagnosis | None | None |
| Z17.2 Progesterone receptor status | ||||
| Z17.21 | Progesterone receptor positive status | Cannot lead a claimUnacceptable principal diagnosis, code is not reportable as principal diagnosis | None | None |
| Z17.22 | Progesterone receptor negative status | Cannot lead a claimUnacceptable principal diagnosis, code is not reportable as principal diagnosis | None | None |
| Z17.3 Human epidermal growth factor 2 receptor | ||||
| Z17.31 | Human epidermal growth factor receptor 2 positive status | Cannot lead a claimPrincipal diagnosis not assigned to a clinical group | None | None |
| Z17.32 | Human epidermal growth factor receptor 2 negative status | Cannot lead a claimPrincipal diagnosis not assigned to a clinical group | None | None |
| Z17.4 Combined receptor status | ||||
| Z17.41 Hormone receptor positive | ||||
| Z17.410 | Hormone receptor positive with human epidermal growth factor receptor 2 positive statusCMS: Hormone recept pos w hmn epdrml grth fctr recept 2 pos stat | Cannot lead a claimPrincipal diagnosis not assigned to a clinical group | None | None |
| Z17.411 | Hormone receptor positive with human epidermal growth factor receptor 2 negative statusCMS: Hormone recept pos w hmn epdrml grth fctr recept 2 neg stat | Cannot lead a claimPrincipal diagnosis not assigned to a clinical group | None | None |
| Z17.42 Hormone receptor negative | ||||
| Z17.420 | Hormone receptor negative with human epidermal growth factor receptor 2 positive statusCMS: Hormone recept neg w hmn epdrml grth fctr recept 2 pos stat | Cannot lead a claimPrincipal diagnosis not assigned to a clinical group | None | None |
| Z17.421 | Hormone receptor negative with human epidermal growth factor receptor 2 negative statusCMS: Hormone recept neg w hmn epdrml grth fctr recept 2 neg stat | Cannot lead a claimPrincipal diagnosis not assigned to a clinical group | None | None |
Sources: CMS HH PPS Grouper Software v07.2.26, effective 2026-10-01, for the clinical group, comorbidity subgroup, code-first conventions and primary-position flags; CDC NCHS ICD-10-CM FY2027 code descriptions for the family title and code wording. This is the crosswalk Medicare runs a claim through. Grouping also depends on admission source, timing, the OASIS functional items and the rest of the diagnosis list.
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