ICD-10 · PDGM grouping
Z15 Genetic susceptibility to disease
All 14 codes in the Z15 family, with the PDGM clinical group, comorbidity subgroup and primary-position rule CMS assigns, read from the CMS grouper crosswalk v07.2.26 and the CDC FY2027 code file.
Codes in family
14
Can lead a claim
0
Cannot lead a claim
14
What CMS assigns to Z15
None of the 14 codes is assigned a clinical group. None of the 14 is assigned a comorbidity subgroup. None can lead a claim. CMS attaches a code-first note to 9 of the 14.
Code first
CMS grouper convention 173, on Z15.01, Z15.02, Z15.03, Z15.04, Z15.05, Z15.060, Z15.068, Z15.07, Z15.09. Code first:
- , if applicable, any current malignant neoplasm (C00-C75, C81-C96)
Every code in Z15
Descriptions are CDC’s FY2027 wording; where CMS’s grouper abbreviates one, its form is shown beneath.
| Code | Description | Primary position | Clinical group | Comorbidity subgroup |
|---|---|---|---|---|
| Z15.0 Genetic susceptibility to malignant neoplasm | ||||
| Z15.01 | Genetic susceptibility to malignant neoplasm of breast | Cannot lead a claimPrincipal diagnosis not assigned to a clinical group | None | None |
| Z15.02 | Genetic susceptibility to malignant neoplasm of ovary | Cannot lead a claimPrincipal diagnosis not assigned to a clinical group | None | None |
| Z15.03 | Genetic susceptibility to malignant neoplasm of prostate | Cannot lead a claimPrincipal diagnosis not assigned to a clinical group | None | None |
| Z15.04 | Genetic susceptibility to malignant neoplasm of endometrium | Cannot lead a claimPrincipal diagnosis not assigned to a clinical group | None | None |
| Z15.05 | Genetic susceptibility to malignant neoplasm of fallopian tube(s)CMS: Genetic susceptibility to malignant neoplasm of fallop(s) | Cannot lead a claimUnacceptable principal diagnosis, code is not reportable as principal diagnosis | None | None |
| Z15.06 Genetic susceptibility to malignant neoplasm of digestive system | ||||
| Z15.060 | Genetic susceptibility to colorectal cancer | Cannot lead a claimUnacceptable principal diagnosis, code is not reportable as principal diagnosis | None | None |
| Z15.068 | Genetic susceptibility to other malignant neoplasm of digestive systemCMS: Genetic susceptibility to other malig neoplasm of dgstv sys | Cannot lead a claimUnacceptable principal diagnosis, code is not reportable as principal diagnosis | None | None |
| Z15.07 | Genetic susceptibility to malignant neoplasm of urinary tractCMS: Genetic susceptibility to malig neoplasm of urinary tract | Cannot lead a claimUnacceptable principal diagnosis, code is not reportable as principal diagnosis | None | None |
| Z15.09 | Genetic susceptibility to other malignant neoplasm | Cannot lead a claimPrincipal diagnosis not assigned to a clinical group | None | None |
| Z15.1 | Genetic susceptibility to epilepsy and neurodevelopmental disordersCMS: Genetic susceptibility to epi and neurodevelopmental disord | Cannot lead a claimPrincipal diagnosis not assigned to a clinical group | None | None |
| Z15.2 | Genetic susceptibility to obesity | Cannot lead a claimPrincipal diagnosis not assigned to a clinical group | None | None |
| Z15.3 | Genetic susceptibility to kidney disease | Cannot lead a claimUnacceptable principal diagnosis, code is not reportable as principal diagnosis | None | None |
| Z15.8 Genetic susceptibility to other disease | ||||
| Z15.81 | Genetic susceptibility to multiple endocrine neoplasia [MEN] | Cannot lead a claimPrincipal diagnosis not assigned to a clinical group | None | None |
| Z15.89 | Genetic susceptibility to other disease | Cannot lead a claimPrincipal diagnosis not assigned to a clinical group | None | None |
Sources: CMS HH PPS Grouper Software v07.2.26, effective 2026-10-01, for the clinical group, comorbidity subgroup, code-first conventions and primary-position flags; CDC NCHS ICD-10-CM FY2027 code descriptions for the family title and code wording. This is the crosswalk Medicare runs a claim through. Grouping also depends on admission source, timing, the OASIS functional items and the rest of the diagnosis list.
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