ICD-10 · PDGM grouping
C45-C49 — Malignant neoplasms of mesothelial and soft tissue
Every ICD-10-CM code in this range and the PDGM clinical group CMS assigns to it, read from the CMS grouper crosswalk v07.2.26.
Codes in range
52
No clinical group
9
A period cannot be grouped from these.
Barred as primary
0
CMS rejects these in the primary position.
Where these codes group
43 of the 52 codes in C45-C49 group to MMTA - Infectious Disease, Neoplasms, and Blood-Forming Diseases. A further 9 are assigned no clinical group at all, which means a 30-day period cannot be grouped from them.
Code families in C45-C49
One page per three-character family: every code in it, whether it can lead a claim, its clinical group and comorbidity subgroup.
Every code in C45-C49
Descriptions are CMS’s own, abbreviated as CMS abbreviates them.
| Code | Description | Clinical group | Primary position |
|---|---|---|---|
| C450 | Mesothelioma of pleura | K | Can lead a claim |
| C451 | Mesothelioma of peritoneum | K | Can lead a claim |
| C452 | Mesothelioma of pericardium | K | Can lead a claim |
| C457 | Mesothelioma of other sites | K | Can lead a claim |
| C459 | Mesothelioma, unspecified | None | Cannot lead a claim |
| C460 | Kaposi's sarcoma of skin | K | Can lead a claim, code first applies |
| C461 | Kaposi's sarcoma of soft tissue | K | Can lead a claim, code first applies |
| C462 | Kaposi's sarcoma of palate | K | Can lead a claim, code first applies |
| C463 | Kaposi's sarcoma of lymph nodes | K | Can lead a claim, code first applies |
| C464 | Kaposi's sarcoma of gastrointestinal sites | K | Can lead a claim, code first applies |
| C4650 | Kaposi's sarcoma of unspecified lung | None | Cannot lead a claim |
| C4651 | Kaposi's sarcoma of right lung | K | Can lead a claim, code first applies |
| C4652 | Kaposi's sarcoma of left lung | K | Can lead a claim, code first applies |
| C467 | Kaposi's sarcoma of other sites | K | Can lead a claim, code first applies |
| C469 | Kaposi's sarcoma, unspecified | None | Cannot lead a claim |
| C470 | Malignant neoplasm of prph nerves of head, face and neck | K | Can lead a claim |
| C4710 | Malig neoplm of prph nerves of unsp upper limb, inc shoulder | None | Cannot lead a claim |
| C4711 | Malig neoplm of prph nerves of right upper limb, inc shldr | K | Can lead a claim |
| C4712 | Malig neoplm of prph nerves of left upper limb, inc shoulder | K | Can lead a claim |
| C4720 | Malig neoplasm of prph nerves of unsp lower limb, inc hip | None | Cannot lead a claim |
| C4721 | Malig neoplasm of prph nerves of right lower limb, inc hip | K | Can lead a claim |
| C4722 | Malig neoplasm of prph nerves of left lower limb, inc hip | K | Can lead a claim |
| C473 | Malignant neoplasm of peripheral nerves of thorax | K | Can lead a claim |
| C474 | Malignant neoplasm of peripheral nerves of abdomen | K | Can lead a claim |
| C475 | Malignant neoplasm of peripheral nerves of pelvis | K | Can lead a claim |
| C476 | Malignant neoplasm of peripheral nerves of trunk, unsp | K | Can lead a claim |
| C478 | Malig neoplm of ovrlp sites of prph nrv and autonm nrv sys | K | Can lead a claim |
| C479 | Malig neoplasm of prph nerves and autonm nervous sys, unsp | K | Can lead a claim |
| C480 | Malignant neoplasm of retroperitoneum | K | Can lead a claim |
| C481 | Malignant neoplasm of specified parts of peritoneum | K | Can lead a claim |
| C482 | Malignant neoplasm of peritoneum, unspecified | K | Can lead a claim |
| C488 | Malig neoplasm of ovrlp sites of retroperiton and peritoneum | K | Can lead a claim |
| C490 | Malig neoplm of conn and soft tissue of head, face and neck | K | Can lead a claim |
| C4910 | Malig neoplm of conn & soft tiss of unsp upr lmb, inc shldr | None | Cannot lead a claim |
| C4911 | Malig neoplm of conn and soft tiss of r upr limb, inc shldr | K | Can lead a claim |
| C4912 | Malig neoplm of conn and soft tiss of l upr limb, inc shldr | K | Can lead a claim |
| C4920 | Malig neoplm of conn and soft tiss of unsp low limb, inc hip | None | Cannot lead a claim |
| C4921 | Malig neoplm of conn and soft tiss of r low limb, inc hip | K | Can lead a claim |
| C4922 | Malig neoplm of conn and soft tiss of left low limb, inc hip | K | Can lead a claim |
| C493 | Malignant neoplasm of connective and soft tissue of thorax | K | Can lead a claim |
| C494 | Malignant neoplasm of connective and soft tissue of abdomen | K | Can lead a claim |
| C495 | Malignant neoplasm of connective and soft tissue of pelvis | K | Can lead a claim |
| C496 | Malignant neoplasm of conn and soft tissue of trunk, unsp | K | Can lead a claim |
| C498 | Malignant neoplasm of ovrlp sites of conn and soft tissue | K | Can lead a claim |
| C499 | Malignant neoplasm of connective and soft tissue, unsp | None | Cannot lead a claim |
| C49A0 | Gastrointestinal stromal tumor, unspecified site | None | Cannot lead a claim |
| C49A1 | Gastrointestinal stromal tumor of esophagus | K | Can lead a claim |
| C49A2 | Gastrointestinal stromal tumor of stomach | K | Can lead a claim |
| C49A3 | Gastrointestinal stromal tumor of small intestine | K | Can lead a claim |
| C49A4 | Gastrointestinal stromal tumor of large intestine | K | Can lead a claim |
| C49A5 | Gastrointestinal stromal tumor of rectum | K | Can lead a claim |
| C49A9 | Gastrointestinal stromal tumor of other sites | K | Can lead a claim |
Source: CMS HH PPS Grouper Software v07.2.26, effective 2026-10-01. This is the crosswalk Medicare runs a claim through. Grouping also depends on admission source, timing, the OASIS functional items and the rest of the diagnosis list.
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