ICD-10 · PDGM grouping
C49 Malignant neoplasm of other connective and soft tissue
All 20 codes in the C49 family, with the PDGM clinical group, comorbidity subgroup and primary-position rule CMS assigns, read from the CMS grouper crosswalk v07.2.26 and the CDC FY2027 code file.
Codes in family
20
Can lead a claim
16
Cannot lead a claim
4
What CMS assigns to C49
16 of the 20 codes group to MMTA - Infectious Disease, Neoplasms, and Blood-Forming Diseases; 4 are assigned no clinical group. 16 of the 20 count toward the Malignant Neoplasm of Peripheral Nerves, Autonomic Nervous System, and other connective tissue comorbidity subgroup; 4 are assigned none. 16 of the 20 can lead a claim.
- Malignant Neoplasm of Peripheral Nerves, Autonomic Nervous System, and other connective tissue
Every code in C49
Descriptions are CDC’s FY2027 wording; where CMS’s grouper abbreviates one, its form is shown beneath.
| Code | Description | Primary position | Clinical group | Comorbidity subgroup |
|---|---|---|---|---|
| C49.0 | Malignant neoplasm of connective and soft tissue of head, face and neckCMS: Malig neoplm of conn and soft tissue of head, face and neck | Can lead a claim | K | Malignant Neoplasm of Peripheral Nerves, Autonomic Nervous System, and other connective tissue |
| C49.1 Malignant neoplasm of connective and soft tissue of upper limb, including shoulder | ||||
| C49.10 | Malignant neoplasm of connective and soft tissue of unspecified upper limb, including shoulderCMS: Malig neoplm of conn & soft tiss of unsp upr lmb, inc shldr | Cannot lead a claimPrincipal diagnosis not assigned to a clinical group | None | None |
| C49.11 | Malignant neoplasm of connective and soft tissue of right upper limb, including shoulderCMS: Malig neoplm of conn and soft tiss of r upr limb, inc shldr | Can lead a claim | K | Malignant Neoplasm of Peripheral Nerves, Autonomic Nervous System, and other connective tissue |
| C49.12 | Malignant neoplasm of connective and soft tissue of left upper limb, including shoulderCMS: Malig neoplm of conn and soft tiss of l upr limb, inc shldr | Can lead a claim | K | Malignant Neoplasm of Peripheral Nerves, Autonomic Nervous System, and other connective tissue |
| C49.2 Malignant neoplasm of connective and soft tissue of lower limb, including hip | ||||
| C49.20 | Malignant neoplasm of connective and soft tissue of unspecified lower limb, including hipCMS: Malig neoplm of conn and soft tiss of unsp low limb, inc hip | Cannot lead a claimPrincipal diagnosis not assigned to a clinical group | None | None |
| C49.21 | Malignant neoplasm of connective and soft tissue of right lower limb, including hipCMS: Malig neoplm of conn and soft tiss of r low limb, inc hip | Can lead a claim | K | Malignant Neoplasm of Peripheral Nerves, Autonomic Nervous System, and other connective tissue |
| C49.22 | Malignant neoplasm of connective and soft tissue of left lower limb, including hipCMS: Malig neoplm of conn and soft tiss of left low limb, inc hip | Can lead a claim | K | Malignant Neoplasm of Peripheral Nerves, Autonomic Nervous System, and other connective tissue |
| C49.3 | Malignant neoplasm of connective and soft tissue of thorax | Can lead a claim | K | Malignant Neoplasm of Peripheral Nerves, Autonomic Nervous System, and other connective tissue |
| C49.4 | Malignant neoplasm of connective and soft tissue of abdomen | Can lead a claim | K | Malignant Neoplasm of Peripheral Nerves, Autonomic Nervous System, and other connective tissue |
| C49.5 | Malignant neoplasm of connective and soft tissue of pelvis | Can lead a claim | K | Malignant Neoplasm of Peripheral Nerves, Autonomic Nervous System, and other connective tissue |
| C49.6 | Malignant neoplasm of connective and soft tissue of trunk, unspecifiedCMS: Malignant neoplasm of conn and soft tissue of trunk, unsp | Can lead a claim | K | Malignant Neoplasm of Peripheral Nerves, Autonomic Nervous System, and other connective tissue |
| C49.8 | Malignant neoplasm of overlapping sites of connective and soft tissueCMS: Malignant neoplasm of ovrlp sites of conn and soft tissue | Can lead a claim | K | Malignant Neoplasm of Peripheral Nerves, Autonomic Nervous System, and other connective tissue |
| C49.9 | Malignant neoplasm of connective and soft tissue, unspecifiedCMS: Malignant neoplasm of connective and soft tissue, unsp | Cannot lead a claimPrincipal diagnosis not assigned to a clinical group | None | None |
| C49.A Gastrointestinal stromal tumor | ||||
| C49.A0 | Gastrointestinal stromal tumor, unspecified site | Cannot lead a claimPrincipal diagnosis not assigned to a clinical group | None | None |
| C49.A1 | Gastrointestinal stromal tumor of esophagus | Can lead a claim | K | Malignant Neoplasm of Peripheral Nerves, Autonomic Nervous System, and other connective tissue |
| C49.A2 | Gastrointestinal stromal tumor of stomach | Can lead a claim | K | Malignant Neoplasm of Peripheral Nerves, Autonomic Nervous System, and other connective tissue |
| C49.A3 | Gastrointestinal stromal tumor of small intestine | Can lead a claim | K | Malignant Neoplasm of Peripheral Nerves, Autonomic Nervous System, and other connective tissue |
| C49.A4 | Gastrointestinal stromal tumor of large intestine | Can lead a claim | K | Malignant Neoplasm of Peripheral Nerves, Autonomic Nervous System, and other connective tissue |
| C49.A5 | Gastrointestinal stromal tumor of rectum | Can lead a claim | K | Malignant Neoplasm of Peripheral Nerves, Autonomic Nervous System, and other connective tissue |
| C49.A9 | Gastrointestinal stromal tumor of other sites | Can lead a claim | K | Malignant Neoplasm of Peripheral Nerves, Autonomic Nervous System, and other connective tissue |
Sources: CMS HH PPS Grouper Software v07.2.26, effective 2026-10-01, for the clinical group, comorbidity subgroup, code-first conventions and primary-position flags; CDC NCHS ICD-10-CM FY2027 code descriptions for the family title and code wording. This is the crosswalk Medicare runs a claim through. Grouping also depends on admission source, timing, the OASIS functional items and the rest of the diagnosis list.
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