ICD-10 · PDGM grouping
D57 Sickle-cell disorders
All 43 codes in the D57 family, with the PDGM clinical group, comorbidity subgroup and primary-position rule CMS assigns, read from the CMS grouper crosswalk v07.2.26 and the CDC FY2027 code file.
ICD-10-CM FY2027 · CMS grouper v07.2.26
Codes in family
43
Can lead a claim
42
Cannot lead a claim
1
What CMS assigns to D57
42 of the 43 codes group to MMTA - Infectious Disease, Neoplasms, and Blood-Forming Diseases (36) and Neuro Rehabilitation (6); 1 is assigned no clinical group. 42 of the 43 count toward the Hemolytic, Aplastic, and Other Anemias comorbidity subgroup; 1 is assigned none. 42 of the 43 can lead a claim.
- Hemolytic, Aplastic, and Other Anemias: can award the low comorbidity tier as a secondary diagnosis.
Every code in D57
Descriptions are CDC’s FY2027 wording; where CMS’s grouper abbreviates one, its form is shown beneath.
| Code | Description | Primary position | Clinical group | Comorbidity subgroup |
|---|---|---|---|---|
| D57.0 Hb-SS disease with crisis | ||||
| D57.00 | Hb-SS disease with crisis, unspecified | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.01 | Hb-SS disease with acute chest syndrome | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.02 | Hb-SS disease with splenic sequestration | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.03 | Hb-SS disease with cerebral vascular involvement | Can lead a claim | B | Hemolytic, Aplastic, and Other Anemias |
| D57.04 | Hb-SS disease with dactylitis | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.09 | Hb-SS disease with crisis with other specified complication | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.1 | Sickle-cell disease without crisis | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.2 Sickle-cell/Hb-C disease | ||||
| D57.20 | Sickle-cell/Hb-C disease without crisis | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.21 Sickle-cell/Hb-C disease with crisis | ||||
| D57.211 | Sickle-cell/Hb-C disease with acute chest syndrome | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.212 | Sickle-cell/Hb-C disease with splenic sequestration | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.213 | Sickle-cell/Hb-C disease with cerebral vascular involvement | Can lead a claim | B | Hemolytic, Aplastic, and Other Anemias |
| D57.214 | Sickle-cell/Hb-C disease with dactylitis | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.218 | Sickle-cell/Hb-C disease with crisis with other specified complicationCMS: Sickle-cell/Hb-C disease with crisis with oth complication | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.219 | Sickle-cell/Hb-C disease with crisis, unspecified | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.3 | Sickle-cell trait | Cannot lead a claimPrincipal diagnosis not assigned to a clinical group | None | None |
| D57.4 Sickle-cell thalassemia | ||||
| D57.40 | Sickle-cell thalassemia without crisis | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.41 Sickle-cell thalassemia, unspecified, with crisis | ||||
| D57.411 | Sickle-cell thalassemia, unspecified, with acute chest syndromeCMS: Sickle-cell thalassemia, unsp, with acute chest syndrome | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.412 | Sickle-cell thalassemia, unspecified, with splenic sequestrationCMS: Sickle-cell thalassemia, unsp, with splenic sequestration | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.413 | Sickle-cell thalassemia, unspecified, with cerebral vascular involvementCMS: Sickle-cell thalassemia, unsp, with cerebral vascular invl | Can lead a claim | B | Hemolytic, Aplastic, and Other Anemias |
| D57.414 | Sickle-cell thalassemia, unspecified, with dactylitis | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.418 | Sickle-cell thalassemia, unspecified, with crisis with other specified complicationCMS: Sickle-cell thalassemia, unsp, with crisis with oth comp | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.419 | Sickle-cell thalassemia, unspecified, with crisis | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.42 | Sickle-cell thalassemia beta zero without crisis | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.43 Sickle-cell thalassemia beta zero with crisis | ||||
| D57.431 | Sickle-cell thalassemia beta zero with acute chest syndrome | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.432 | Sickle-cell thalassemia beta zero with splenic sequestration | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.433 | Sickle-cell thalassemia beta zero with cerebral vascular involvementCMS: Sickle-cell thalassemia beta zero with cereb vascular invl | Can lead a claim | B | Hemolytic, Aplastic, and Other Anemias |
| D57.434 | Sickle-cell thalassemia beta zero with dactylitis | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.438 | Sickle-cell thalassemia beta zero with crisis with other specified complicationCMS: Sickle-cell thalassemia beta zero with crisis with oth comp | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.439 | Sickle-cell thalassemia beta zero with crisis, unspecified | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.44 | Sickle-cell thalassemia beta plus without crisis | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.45 Sickle-cell thalassemia beta plus with crisis | ||||
| D57.451 | Sickle-cell thalassemia beta plus with acute chest syndrome | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.452 | Sickle-cell thalassemia beta plus with splenic sequestration | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.453 | Sickle-cell thalassemia beta plus with cerebral vascular involvementCMS: Sickle-cell thalassemia beta plus with cereb vascular invl | Can lead a claim | B | Hemolytic, Aplastic, and Other Anemias |
| D57.454 | Sickle-cell thalassemia beta plus with dactylitis | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.458 | Sickle-cell thalassemia beta plus with crisis with other specified complicationCMS: Sickle-cell thalassemia beta plus with crisis with oth comp | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.459 | Sickle-cell thalassemia beta plus with crisis, unspecified | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.8 Other sickle-cell disorders | ||||
| D57.80 | Other sickle-cell disorders without crisis | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.81 Other sickle-cell disorders with crisis | ||||
| D57.811 | Other sickle-cell disorders with acute chest syndrome | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.812 | Other sickle-cell disorders with splenic sequestration | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.813 | Other sickle-cell disorders with cerebral vascular involvementCMS: Other sickle-cell disorders with cerebral vascular invl | Can lead a claim | B | Hemolytic, Aplastic, and Other Anemias |
| D57.814 | Other sickle-cell disorders with dactylitis | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.818 | Other sickle-cell disorders with crisis with other specified complicationCMS: Other sickle-cell disorders with crisis with oth comp | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
| D57.819 | Other sickle-cell disorders with crisis, unspecified | Can lead a claim | K | Hemolytic, Aplastic, and Other Anemias |
Sources: CMS HH PPS Grouper Software v07.2.26, effective 2026-10-01, for the clinical group, comorbidity subgroup, code-first conventions and primary-position flags; CDC NCHS ICD-10-CM FY2027 code descriptions for the family title and code wording. This is the crosswalk Medicare runs a claim through. Grouping also depends on admission source, timing, the OASIS functional items and the rest of the diagnosis list.
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