ICD-10 · PDGM grouping
D55-D59 — Hemolytic anemias
Every ICD-10-CM code in this range and the PDGM clinical group CMS assigns to it, read from the CMS grouper crosswalk v07.2.26.
ICD-10-CM FY2027 · CMS grouper v07.2.26
Codes in range
79
No clinical group
1
A period cannot be grouped from these.
Barred as primary
0
CMS rejects these in the primary position.
Where these codes group
72 of the 79 codes in D55-D59 group to MMTA - Infectious Disease, Neoplasms, and Blood-Forming Diseases, but the range is not uniform — it spreads across 2 clinical groups. A further 1 are assigned no clinical group at all, which means a 30-day period cannot be grouped from them.
Code families in D55-D59
One page per three-character family: every code in it, whether it can lead a claim, its clinical group and comorbidity subgroup.
Every code in D55-D59
Descriptions are CMS’s own, abbreviated as CMS abbreviates them.
| Code | Description | Clinical group | Primary position |
|---|---|---|---|
| D550 | Anemia due to glucose-6-phosphate dehydrogenase deficiency | K | Can lead a claim |
| D551 | Anemia due to other disorders of glutathione metabolism | K | Can lead a claim |
| D5521 | Anemia due to pyruvate kinase deficiency | K | Can lead a claim |
| D5529 | Anemia due to other disorders of glycolytic enzymes | K | Can lead a claim |
| D553 | Anemia due to disorders of nucleotide metabolism | K | Can lead a claim |
| D558 | Other anemias due to enzyme disorders | K | Can lead a claim |
| D559 | Anemia due to enzyme disorder, unspecified | K | Can lead a claim |
| D560 | Alpha thalassemia | K | Can lead a claim |
| D561 | Beta thalassemia | K | Can lead a claim |
| D562 | Delta-beta thalassemia | K | Can lead a claim |
| D563 | Thalassemia minor | K | Can lead a claim |
| D564 | Hereditary persistence of fetal hemoglobin [HPFH] | K | Can lead a claim |
| D565 | Hemoglobin E-beta thalassemia | K | Can lead a claim |
| D568 | Other thalassemias | K | Can lead a claim |
| D569 | Thalassemia, unspecified | K | Can lead a claim |
| D5700 | Hb-SS disease with crisis, unspecified | K | Can lead a claim |
| D5701 | Hb-SS disease with acute chest syndrome | K | Can lead a claim |
| D5702 | Hb-SS disease with splenic sequestration | K | Can lead a claim |
| D5703 | Hb-SS disease with cerebral vascular involvement | B | Can lead a claim |
| D5704 | Hb-SS disease with dactylitis | K | Can lead a claim |
| D5709 | Hb-SS disease with crisis with other specified complication | K | Can lead a claim |
| D571 | Sickle-cell disease without crisis | K | Can lead a claim |
| D5720 | Sickle-cell/Hb-C disease without crisis | K | Can lead a claim |
| D57211 | Sickle-cell/Hb-C disease with acute chest syndrome | K | Can lead a claim |
| D57212 | Sickle-cell/Hb-C disease with splenic sequestration | K | Can lead a claim |
| D57213 | Sickle-cell/Hb-C disease with cerebral vascular involvement | B | Can lead a claim |
| D57214 | Sickle-cell/Hb-C disease with dactylitis | K | Can lead a claim |
| D57218 | Sickle-cell/Hb-C disease with crisis with oth complication | K | Can lead a claim |
| D57219 | Sickle-cell/Hb-C disease with crisis, unspecified | K | Can lead a claim |
| D573 | Sickle-cell trait | None | Cannot lead a claim |
| D5740 | Sickle-cell thalassemia without crisis | K | Can lead a claim |
| D57411 | Sickle-cell thalassemia, unsp, with acute chest syndrome | K | Can lead a claim |
| D57412 | Sickle-cell thalassemia, unsp, with splenic sequestration | K | Can lead a claim |
| D57413 | Sickle-cell thalassemia, unsp, with cerebral vascular invl | B | Can lead a claim |
| D57414 | Sickle-cell thalassemia, unspecified, with dactylitis | K | Can lead a claim |
| D57418 | Sickle-cell thalassemia, unsp, with crisis with oth comp | K | Can lead a claim |
| D57419 | Sickle-cell thalassemia, unspecified, with crisis | K | Can lead a claim |
| D5742 | Sickle-cell thalassemia beta zero without crisis | K | Can lead a claim |
| D57431 | Sickle-cell thalassemia beta zero with acute chest syndrome | K | Can lead a claim |
| D57432 | Sickle-cell thalassemia beta zero with splenic sequestration | K | Can lead a claim |
| D57433 | Sickle-cell thalassemia beta zero with cereb vascular invl | B | Can lead a claim |
| D57434 | Sickle-cell thalassemia beta zero with dactylitis | K | Can lead a claim |
| D57438 | Sickle-cell thalassemia beta zero with crisis with oth comp | K | Can lead a claim |
| D57439 | Sickle-cell thalassemia beta zero with crisis, unspecified | K | Can lead a claim |
| D5744 | Sickle-cell thalassemia beta plus without crisis | K | Can lead a claim |
| D57451 | Sickle-cell thalassemia beta plus with acute chest syndrome | K | Can lead a claim |
| D57452 | Sickle-cell thalassemia beta plus with splenic sequestration | K | Can lead a claim |
| D57453 | Sickle-cell thalassemia beta plus with cereb vascular invl | B | Can lead a claim |
| D57454 | Sickle-cell thalassemia beta plus with dactylitis | K | Can lead a claim |
| D57458 | Sickle-cell thalassemia beta plus with crisis with oth comp | K | Can lead a claim |
| D57459 | Sickle-cell thalassemia beta plus with crisis, unspecified | K | Can lead a claim |
| D5780 | Other sickle-cell disorders without crisis | K | Can lead a claim |
| D57811 | Other sickle-cell disorders with acute chest syndrome | K | Can lead a claim |
| D57812 | Other sickle-cell disorders with splenic sequestration | K | Can lead a claim |
| D57813 | Other sickle-cell disorders with cerebral vascular invl | B | Can lead a claim |
| D57814 | Other sickle-cell disorders with dactylitis | K | Can lead a claim |
| D57818 | Other sickle-cell disorders with crisis with oth comp | K | Can lead a claim |
| D57819 | Other sickle-cell disorders with crisis, unspecified | K | Can lead a claim |
| D580 | Hereditary spherocytosis | K | Can lead a claim |
| D581 | Hereditary elliptocytosis | K | Can lead a claim |
| D582 | Other hemoglobinopathies | K | Can lead a claim |
| D588 | Other specified hereditary hemolytic anemias | K | Can lead a claim |
| D589 | Hereditary hemolytic anemia, unspecified | K | Can lead a claim |
| D590 | Drug-induced autoimmune hemolytic anemia | K | Can lead a claim |
| D5910 | Autoimmune hemolytic anemia, unspecified | K | Can lead a claim |
| D5911 | Warm autoimmune hemolytic anemia | K | Can lead a claim |
| D5912 | Cold autoimmune hemolytic anemia | K | Can lead a claim |
| D5913 | Mixed type autoimmune hemolytic anemia | K | Can lead a claim |
| D5919 | Other autoimmune hemolytic anemia | K | Can lead a claim |
| D592 | Drug-induced nonautoimmune hemolytic anemia | K | Can lead a claim |
| D5930 | Hemolytic-uremic syndrome, unspecified | K | Can lead a claim |
| D5931 | Infection-associated hemolytic-uremic syndrome | K | Can lead a claim |
| D5932 | Hereditary hemolytic-uremic syndrome | K | Can lead a claim |
| D5939 | Other hemolytic-uremic syndrome | K | Can lead a claim, code first applies |
| D594 | Other nonautoimmune hemolytic anemias | K | Can lead a claim |
| D595 | Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli] | K | Can lead a claim |
| D596 | Hemoglobinuria due to hemolysis from other external causes | K | Can lead a claim |
| D598 | Other acquired hemolytic anemias | K | Can lead a claim |
| D599 | Acquired hemolytic anemia, unspecified | K | Can lead a claim |
Source: CMS HH PPS Grouper Software v07.2.26, effective 2026-10-01. This is the crosswalk Medicare runs a claim through. Grouping also depends on admission source, timing, the OASIS functional items and the rest of the diagnosis list.
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