ICD-10 · PDGM grouping
D55 Anemia due to enzyme disorders
All 7 codes in the D55 family, with the PDGM clinical group, comorbidity subgroup and primary-position rule CMS assigns, read from the CMS grouper crosswalk v07.2.26 and the CDC FY2027 code file.
Codes in family
7
Can lead a claim
7
Cannot lead a claim
0
What CMS assigns to D55
All 7 codes group to MMTA - Infectious Disease, Neoplasms, and Blood-Forming Diseases. All 7 count toward the Nutritional, Enzymatic, and Other Heredity Anemias comorbidity subgroup. Every code can lead a claim.
- Nutritional, Enzymatic, and Other Heredity Anemias: counts toward the high comorbidity tier only in an interaction pair.
Every code in D55
Descriptions are CDC’s FY2027 wording; where CMS’s grouper abbreviates one, its form is shown beneath.
| Code | Description | Primary position | Clinical group | Comorbidity subgroup |
|---|---|---|---|---|
| D55.0 | Anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiencyCMS: Anemia due to glucose-6-phosphate dehydrogenase deficiency | Can lead a claim | K | Nutritional, Enzymatic, and Other Heredity Anemias |
| D55.1 | Anemia due to other disorders of glutathione metabolism | Can lead a claim | K | Nutritional, Enzymatic, and Other Heredity Anemias |
| D55.2 Anemia due to disorders of glycolytic enzymes | ||||
| D55.21 | Anemia due to pyruvate kinase deficiency | Can lead a claim | K | Nutritional, Enzymatic, and Other Heredity Anemias |
| D55.29 | Anemia due to other disorders of glycolytic enzymes | Can lead a claim | K | Nutritional, Enzymatic, and Other Heredity Anemias |
| D55.3 | Anemia due to disorders of nucleotide metabolism | Can lead a claim | K | Nutritional, Enzymatic, and Other Heredity Anemias |
| D55.8 | Other anemias due to enzyme disorders | Can lead a claim | K | Nutritional, Enzymatic, and Other Heredity Anemias |
| D55.9 | Anemia due to enzyme disorder, unspecified | Can lead a claim | K | Nutritional, Enzymatic, and Other Heredity Anemias |
Sources: CMS HH PPS Grouper Software v07.2.26, effective 2026-10-01, for the clinical group, comorbidity subgroup, code-first conventions and primary-position flags; CDC NCHS ICD-10-CM FY2027 code descriptions for the family title and code wording. This is the crosswalk Medicare runs a claim through. Grouping also depends on admission source, timing, the OASIS functional items and the rest of the diagnosis list.
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