October 1 update. Our PDGM and ICD-10 tools now use the FY2027 code set: 190 codes added, 30 deleted, and no existing code changed clinical group.

See what changed

ICD-10 · PDGM grouping

A41 Other sepsis

All 15 codes in the A41 family, with the PDGM clinical group, comorbidity subgroup and primary-position rule CMS assigns, read from the CMS grouper crosswalk v07.2.26 and the CDC FY2027 code file.

ICD-10-CM FY2027 · CMS grouper v07.2.26

Codes in family

15

Can lead a claim

15

Cannot lead a claim

0

What CMS assigns to A41

All 15 codes group to MMTA - Infectious Disease, Neoplasms, and Blood-Forming Diseases. All 15 count toward the C-diff, MRSA, E-coli, Sepsis comorbidity subgroup. Every code can lead a claim. CMS attaches a code-first note to all 15.

  • C-diff, MRSA, E-coli, Sepsis: counts toward the high comorbidity tier only in an interaction pair.

Code first

CMS grouper convention 1, on all 15 codes. Code first:

  • , if applicable, postprocedural sepsis (T81.44-)
  • sepsis due to central venous catheter (T80.211-)
  • streptococcal sepsis during labor (O75.3)
  • streptococcal sepsis following abortion or ectopic or molar pregnancy (O03.37, O03.87, O04.87, O07.37, O08.82)
  • streptococcal sepsis following immunization (T88.0-)
  • streptococcal sepsis following infusion, transfusion or therapeutic injection (T80.22-, T80.29-)

Every code in A41

Descriptions are CDC’s FY2027 wording; where CMS’s grouper abbreviates one, its form is shown beneath.

CodeDescriptionPrimary positionClinical groupComorbidity subgroup
A41.0 Sepsis due to Staphylococcus aureus
A41.01Sepsis due to Methicillin susceptible Staphylococcus aureusCan lead a claim, code first appliesKC-diff, MRSA, E-coli, Sepsis
A41.02Sepsis due to Methicillin resistant Staphylococcus aureusCan lead a claim, code first appliesKC-diff, MRSA, E-coli, Sepsis
A41.1Sepsis due to other specified staphylococcusCan lead a claim, code first appliesKC-diff, MRSA, E-coli, Sepsis
A41.2Sepsis due to unspecified staphylococcusCan lead a claim, code first appliesKC-diff, MRSA, E-coli, Sepsis
A41.3Sepsis due to Hemophilus influenzaeCan lead a claim, code first appliesKC-diff, MRSA, E-coli, Sepsis
A41.4Sepsis due to anaerobesCan lead a claim, code first appliesKC-diff, MRSA, E-coli, Sepsis
A41.5 Sepsis due to other Gram-negative organisms
A41.50Gram-negative sepsis, unspecifiedCan lead a claim, code first appliesKC-diff, MRSA, E-coli, Sepsis
A41.51Sepsis due to Escherichia coli [E. coli]Can lead a claim, code first appliesKC-diff, MRSA, E-coli, Sepsis
A41.52Sepsis due to PseudomonasCan lead a claim, code first appliesKC-diff, MRSA, E-coli, Sepsis
A41.53Sepsis due to SerratiaCan lead a claim, code first appliesKC-diff, MRSA, E-coli, Sepsis
A41.54Sepsis due to Acinetobacter baumanniiCan lead a claim, code first appliesKC-diff, MRSA, E-coli, Sepsis
A41.59Other Gram-negative sepsisCan lead a claim, code first appliesKC-diff, MRSA, E-coli, Sepsis
A41.8 Other specified sepsis
A41.81Sepsis due to EnterococcusCan lead a claim, code first appliesKC-diff, MRSA, E-coli, Sepsis
A41.89Other specified sepsisCan lead a claim, code first appliesKC-diff, MRSA, E-coli, Sepsis
A41.9Sepsis, unspecified organismCan lead a claim, code first appliesKC-diff, MRSA, E-coli, Sepsis

Sources: CMS HH PPS Grouper Software v07.2.26, effective 2026-10-01, for the clinical group, comorbidity subgroup, code-first conventions and primary-position flags; CDC NCHS ICD-10-CM FY2027 code descriptions for the family title and code wording. This is the crosswalk Medicare runs a claim through. Grouping also depends on admission source, timing, the OASIS functional items and the rest of the diagnosis list.

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