ICD-10 · PDGM grouping
D80-D89 — Certain disorders involving the immune mechanism
Every ICD-10-CM code in this range and the PDGM clinical group CMS assigns to it, read from the CMS grouper crosswalk v07.2.26.
ICD-10-CM FY2027 · CMS grouper v07.2.26
Codes in range
83
No clinical group
11
A period cannot be grouped from these.
Barred as primary
10
CMS rejects these in the primary position.
Where these codes group
70 of the 83 codes in D80-D89 group to MMTA - Infectious Disease, Neoplasms, and Blood-Forming Diseases, but the range is not uniform — it spreads across 3 clinical groups. A further 11 are assigned no clinical group at all, which means a 30-day period cannot be grouped from them.
Code families in D80-D89
One page per three-character family: every code in it, whether it can lead a claim, its clinical group and comorbidity subgroup.
- D80Immunodeficiency with predominantly antibody defects10 codes
- D81Combined immunodeficiencies17 codes
- D82Immunodeficiency associated with other major defects7 codes
- D83Common variable immunodeficiency5 codes
- D84Other immunodeficiencies7 codes
- D86Sarcoidosis13 codes
- D89Other disorders involving the immune mechanism, not elsewhere classified24 codes
Every code in D80-D89
Descriptions are CMS’s own, abbreviated as CMS abbreviates them.
| Code | Description | Clinical group | Primary position |
|---|---|---|---|
| D800 | Hereditary hypogammaglobulinemia | K | Can lead a claim |
| D801 | Nonfamilial hypogammaglobulinemia | K | Can lead a claim |
| D802 | Selective deficiency of immunoglobulin A [IgA] | K | Can lead a claim |
| D803 | Selective deficiency of immunoglobulin G [IgG] subclasses | K | Can lead a claim |
| D804 | Selective deficiency of immunoglobulin M [IgM] | K | Can lead a claim |
| D805 | Immunodeficiency with increased immunoglobulin M [IgM] | K | Can lead a claim |
| D806 | Antibody defic w near-norm immunoglob or w hyperimmunoglob | K | Can lead a claim |
| D807 | Transient hypogammaglobulinemia of infancy | K | Can lead a claim |
| D808 | Other immunodeficiencies with predominantly antibody defects | K | Can lead a claim |
| D809 | Immunodeficiency with predominantly antibody defects, unsp | K | Can lead a claim |
| D810 | Severe combined immunodeficiency with reticular dysgenesis | K | Can lead a claim |
| D811 | Severe combined immunodeficiency w low T- and B-cell numbers | K | Can lead a claim |
| D812 | Severe combined immunodef w low or normal B-cell numbers | K | Can lead a claim |
| D8130 | Adenosine deaminase deficiency, unspecified | K | Can lead a claim |
| D8131 | Severe combined immunodef due to adenosine deaminase defic | K | Can lead a claim |
| D8132 | Adenosine deaminase 2 deficiency | K | Can lead a claim |
| D8139 | Other adenosine deaminase deficiency | K | Can lead a claim |
| D814 | Nezelof's syndrome | K | Can lead a claim |
| D815 | Purine nucleoside phosphorylase [PNP] deficiency | K | Can lead a claim |
| D816 | Major histocompatibility complex class I deficiency | K | Can lead a claim |
| D817 | Major histocompatibility complex class II deficiency | K | Can lead a claim |
| D81810 | Biotinidase deficiency | K | Can lead a claim |
| D81818 | Other biotin-dependent carboxylase deficiency | K | Can lead a claim |
| D81819 | Biotin-dependent carboxylase deficiency, unspecified | K | Can lead a claim |
| D8182 | Activated Phosphoinositide 3-kinase Delta Syndrome [APDS] | K | Can lead a claim |
| D8189 | Other combined immunodeficiencies | K | Can lead a claim |
| D819 | Combined immunodeficiency, unspecified | K | Can lead a claim |
| D820 | Wiskott-Aldrich syndrome | K | Can lead a claim |
| D821 | Di George's syndrome | K | Can lead a claim |
| D822 | Immunodeficiency with short-limbed stature | K | Can lead a claim |
| D823 | Immunodef fol heredit defctv response to Epstein-Barr virus | K | Can lead a claim |
| D824 | Hyperimmunoglobulin E [IgE] syndrome | K | Can lead a claim |
| D828 | Immunodeficiency associated with oth major defects | K | Can lead a claim |
| D829 | Immunodeficiency associated with major defect, unspecified | K | Can lead a claim |
| D830 | Com variab immunodef w predom abnlt of B-cell nums & functn | K | Can lead a claim |
| D831 | Com variab immunodef w predom immunoreg T-cell disorders | K | Can lead a claim |
| D832 | Common variable immunodef w autoantibodies to B- or T-cells | K | Can lead a claim |
| D838 | Other common variable immunodeficiencies | K | Can lead a claim |
| D839 | Common variable immunodeficiency, unspecified | K | Can lead a claim |
| D840 | Lymphocyte function antigen-1 [LFA-1] defect | K | Can lead a claim |
| D841 | Defects in the complement system | K | Can lead a claim |
| D8481 | Immunodeficiency due to conditions classified elsewhere | None | Cannot lead a claim |
| D84821 | Immunodeficiency due to drugs | K | Can lead a claim |
| D84822 | Immunodeficiency due to external causes | K | Can lead a claim |
| D8489 | Other immunodeficiencies | K | Can lead a claim |
| D849 | Immunodeficiency, unspecified | K | Can lead a claim |
| D860 | Sarcoidosis of lung | K | Can lead a claim |
| D861 | Sarcoidosis of lymph nodes | K | Can lead a claim |
| D862 | Sarcoidosis of lung with sarcoidosis of lymph nodes | K | Can lead a claim |
| D863 | Sarcoidosis of skin | K | Can lead a claim |
| D8681 | Sarcoid meningitis | B | Can lead a claim |
| D8682 | Multiple cranial nerve palsies in sarcoidosis | K | Can lead a claim |
| D8683 | Sarcoid iridocyclitis | K | Can lead a claim |
| D8684 | Sarcoid pyelonephritis | K | Can lead a claim |
| D8685 | Sarcoid myocarditis | K | Can lead a claim |
| D8686 | Sarcoid arthropathy | K | Can lead a claim |
| D8687 | Sarcoid myositis | K | Can lead a claim |
| D8689 | Sarcoidosis of other sites | K | Can lead a claim |
| D869 | Sarcoidosis, unspecified | E | Can lead a claim |
| D890 | Polyclonal hypergammaglobulinemia | K | Can lead a claim |
| D891 | Cryoglobulinemia | K | Can lead a claim |
| D892 | Hypergammaglobulinemia, unspecified | K | Can lead a claim |
| D893 | Immune reconstitution syndrome | K | Can lead a claim |
| D8940 | Mast cell activation, unspecified | K | Can lead a claim |
| D8941 | Monoclonal mast cell activation syndrome | K | Can lead a claim |
| D8942 | Idiopathic mast cell activation syndrome | K | Can lead a claim |
| D8943 | Secondary mast cell activation | K | Can lead a claim |
| D8944 | Hereditary alpha tryptasemia | K | Can lead a claim |
| D8949 | Other mast cell activation disorder | K | Can lead a claim |
| D89810 | Acute graft-versus-host disease | None | Cannot lead a claim |
| D89811 | Chronic graft-versus-host disease | None | Cannot lead a claim |
| D89812 | Acute on chronic graft-versus-host disease | None | Cannot lead a claim |
| D89813 | Graft-versus-host disease, unspecified | None | Cannot lead a claim |
| D8982 | Autoimmune lymphoproliferative syndrome [ALPS] | K | Can lead a claim |
| D89831 | Cytokine release syndrome, grade 1 | None | Cannot lead a claim |
| D89832 | Cytokine release syndrome, grade 2 | None | Cannot lead a claim |
| D89833 | Cytokine release syndrome, grade 3 | None | Cannot lead a claim |
| D89834 | Cytokine release syndrome, grade 4 | None | Cannot lead a claim |
| D89835 | Cytokine release syndrome, grade 5 | None | Cannot lead a claim |
| D89839 | Cytokine release syndrome, grade unspecified | None | Cannot lead a claim |
| D8984 | IgG4-related disease | K | Can lead a claim |
| D8989 | Oth disrd involving the immune mechanism, NEC | K | Can lead a claim |
| D899 | Disorder involving the immune mechanism, unspecified | K | Can lead a claim |
Source: CMS HH PPS Grouper Software v07.2.26, effective 2026-10-01. This is the crosswalk Medicare runs a claim through. Grouping also depends on admission source, timing, the OASIS functional items and the rest of the diagnosis list.
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