ICD-10 · PDGM grouping

D80-D89 — Certain disorders involving the immune mechanism

Every ICD-10-CM code in this range and the PDGM clinical group CMS assigns to it, read from the CMS grouper crosswalk v07.1.26.

OASIS-E2 v1.00.0 · ingested 2026-04-26

Codes in range

No clinical group

A period cannot be grouped from these.

Barred as primary

CMS rejects these in the primary position.

Where these codes group

70 of the 83 codes in D80-D89 group to MMTA - Infectious Disease, Neoplasms, and Blood-Forming Diseases, but the range is not uniform — it spreads across 3 clinical groups. A further 11 are assigned no clinical group at all, which means a 30-day period cannot be grouped from them.

Every code in D80-D89

Descriptions are CMS’s own, abbreviated as CMS abbreviates them.

Code	Description	Clinical group	Primary position
D800	Hereditary hypogammaglobulinemia	K	Accepted
D801	Nonfamilial hypogammaglobulinemia	K	Accepted
D802	Selective deficiency of immunoglobulin A [IgA]	K	Accepted
D803	Selective deficiency of immunoglobulin G [IgG] subclasses	K	Accepted
D804	Selective deficiency of immunoglobulin M [IgM]	K	Accepted
D805	Immunodeficiency with increased immunoglobulin M [IgM]	K	Accepted
D806	Antibody defic w near-norm immunoglob or w hyperimmunoglob	K	Accepted
D807	Transient hypogammaglobulinemia of infancy	K	Accepted
D808	Other immunodeficiencies with predominantly antibody defects	K	Accepted
D809	Immunodeficiency with predominantly antibody defects, unsp	K	Accepted
D810	Severe combined immunodeficiency with reticular dysgenesis	K	Accepted
D811	Severe combined immunodeficiency w low T- and B-cell numbers	K	Accepted
D812	Severe combined immunodef w low or normal B-cell numbers	K	Accepted
D8130	Adenosine deaminase deficiency, unspecified	K	Accepted
D8131	Severe combined immunodef due to adenosine deaminase defic	K	Accepted
D8132	Adenosine deaminase 2 deficiency	K	Accepted
D8139	Other adenosine deaminase deficiency	K	Accepted
D814	Nezelof's syndrome	K	Accepted
D815	Purine nucleoside phosphorylase [PNP] deficiency	K	Accepted
D816	Major histocompatibility complex class I deficiency	K	Accepted
D817	Major histocompatibility complex class II deficiency	K	Accepted
D81810	Biotinidase deficiency	K	Accepted
D81818	Other biotin-dependent carboxylase deficiency	K	Accepted
D81819	Biotin-dependent carboxylase deficiency, unspecified	K	Accepted
D8182	Activated Phosphoinositide 3-kinase Delta Syndrome [APDS]	K	Accepted
D8189	Other combined immunodeficiencies	K	Accepted
D819	Combined immunodeficiency, unspecified	K	Accepted
D820	Wiskott-Aldrich syndrome	K	Accepted
D821	Di George's syndrome	K	Accepted
D822	Immunodeficiency with short-limbed stature	K	Accepted
D823	Immunodef fol heredit defctv response to Epstein-Barr virus	K	Accepted
D824	Hyperimmunoglobulin E [IgE] syndrome	K	Accepted
D828	Immunodeficiency associated with oth major defects	K	Accepted
D829	Immunodeficiency associated with major defect, unspecified	K	Accepted
D830	Com variab immunodef w predom abnlt of B-cell nums & functn	K	Accepted
D831	Com variab immunodef w predom immunoreg T-cell disorders	K	Accepted
D832	Common variable immunodef w autoantibodies to B- or T-cells	K	Accepted
D838	Other common variable immunodeficiencies	K	Accepted
D839	Common variable immunodeficiency, unspecified	K	Accepted
D840	Lymphocyte function antigen-1 [LFA-1] defect	K	Accepted
D841	Defects in the complement system	K	Accepted
D8481	Immunodeficiency due to conditions classified elsewhere	None	Cannot group
D84821	Immunodeficiency due to drugs	K	Accepted
D84822	Immunodeficiency due to external causes	K	Accepted
D8489	Other immunodeficiencies	K	Accepted
D849	Immunodeficiency, unspecified	K	Accepted
D860	Sarcoidosis of lung	K	Accepted
D861	Sarcoidosis of lymph nodes	K	Accepted
D862	Sarcoidosis of lung with sarcoidosis of lymph nodes	K	Accepted
D863	Sarcoidosis of skin	K	Accepted
D8681	Sarcoid meningitis	B	Accepted
D8682	Multiple cranial nerve palsies in sarcoidosis	K	Accepted
D8683	Sarcoid iridocyclitis	K	Accepted
D8684	Sarcoid pyelonephritis	K	Accepted
D8685	Sarcoid myocarditis	K	Accepted
D8686	Sarcoid arthropathy	K	Accepted
D8687	Sarcoid myositis	K	Accepted
D8689	Sarcoidosis of other sites	K	Accepted
D869	Sarcoidosis, unspecified	E	Accepted
D890	Polyclonal hypergammaglobulinemia	K	Accepted
D891	Cryoglobulinemia	K	Accepted
D892	Hypergammaglobulinemia, unspecified	K	Accepted
D893	Immune reconstitution syndrome	K	Accepted
D8940	Mast cell activation, unspecified	K	Accepted
D8941	Monoclonal mast cell activation syndrome	K	Accepted
D8942	Idiopathic mast cell activation syndrome	K	Accepted
D8943	Secondary mast cell activation	K	Accepted
D8944	Hereditary alpha tryptasemia	K	Accepted
D8949	Other mast cell activation disorder	K	Accepted
D89810	Acute graft-versus-host disease	None	Not accepted
D89811	Chronic graft-versus-host disease	None	Not accepted
D89812	Acute on chronic graft-versus-host disease	None	Not accepted
D89813	Graft-versus-host disease, unspecified	None	Not accepted
D8982	Autoimmune lymphoproliferative syndrome [ALPS]	K	Accepted
D89831	Cytokine release syndrome, grade 1	None	Not accepted
D89832	Cytokine release syndrome, grade 2	None	Not accepted
D89833	Cytokine release syndrome, grade 3	None	Not accepted
D89834	Cytokine release syndrome, grade 4	None	Not accepted
D89835	Cytokine release syndrome, grade 5	None	Not accepted
D89839	Cytokine release syndrome, grade unspecified	None	Not accepted
D8984	IgG4-related disease	K	Accepted
D8989	Oth disrd involving the immune mechanism, NEC	K	Accepted
D899	Disorder involving the immune mechanism, unspecified	K	Accepted

Source: CMS HH PPS Grouper Software v07.1.26, effective 2026-04-01. This is the crosswalk Medicare runs a claim through. Grouping also depends on admission source, timing, the OASIS functional items and the rest of the diagnosis list.

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D80-D89 — Certain disorders involving the immune mechanism

Where these codes group

Every code in D80-D89

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