ICD-10 · PDGM grouping
D81 Combined immunodeficiencies
All 17 codes in the D81 family, with the PDGM clinical group, comorbidity subgroup and primary-position rule CMS assigns, read from the CMS grouper crosswalk v07.2.26 and the CDC FY2027 code file.
Codes in family
17
Can lead a claim
17
Cannot lead a claim
0
What CMS assigns to D81
All 17 codes group to MMTA - Infectious Disease, Neoplasms, and Blood-Forming Diseases. 2 of the 17 count toward the Other Combined Immunodeficiencies and Malnutrition, includes graft-versus-host-disease comorbidity subgroup; 15 are assigned none. Every code can lead a claim.
- Other Combined Immunodeficiencies and Malnutrition, includes graft-versus-host-disease: can award the low comorbidity tier as a secondary diagnosis.
Every code in D81
Descriptions are CDC’s FY2027 wording; where CMS’s grouper abbreviates one, its form is shown beneath.
| Code | Description | Primary position | Clinical group | Comorbidity subgroup |
|---|---|---|---|---|
| D81.0 | Severe combined immunodeficiency [SCID] with reticular dysgenesisCMS: Severe combined immunodeficiency with reticular dysgenesis | Can lead a claim | K | None |
| D81.1 | Severe combined immunodeficiency [SCID] with low T- and B-cell numbersCMS: Severe combined immunodeficiency w low T- and B-cell numbers | Can lead a claim | K | None |
| D81.2 | Severe combined immunodeficiency [SCID] with low or normal B-cell numbersCMS: Severe combined immunodef w low or normal B-cell numbers | Can lead a claim | K | None |
| D81.3 Adenosine deaminase [ADA] deficiency | ||||
| D81.30 | Adenosine deaminase deficiency, unspecified | Can lead a claim | K | None |
| D81.31 | Severe combined immunodeficiency due to adenosine deaminase deficiencyCMS: Severe combined immunodef due to adenosine deaminase defic | Can lead a claim | K | None |
| D81.32 | Adenosine deaminase 2 deficiency | Can lead a claim | K | None |
| D81.39 | Other adenosine deaminase deficiency | Can lead a claim | K | None |
| D81.4 | Nezelof's syndrome | Can lead a claim | K | None |
| D81.5 | Purine nucleoside phosphorylase [PNP] deficiency | Can lead a claim | K | None |
| D81.6 | Major histocompatibility complex class I deficiency | Can lead a claim | K | None |
| D81.7 | Major histocompatibility complex class II deficiency | Can lead a claim | K | None |
| D81.8 Other combined immunodeficiencies | ||||
| D81.81 Biotin-dependent carboxylase deficiency | ||||
| D81.810 | Biotinidase deficiency | Can lead a claim | K | None |
| D81.818 | Other biotin-dependent carboxylase deficiency | Can lead a claim | K | Other Combined Immunodeficiencies and Malnutrition, includes graft-versus-host-disease |
| D81.819 | Biotin-dependent carboxylase deficiency, unspecified | Can lead a claim | K | Other Combined Immunodeficiencies and Malnutrition, includes graft-versus-host-disease |
| D81.82 | Activated Phosphoinositide 3-kinase Delta Syndrome [APDS] | Can lead a claim | K | None |
| D81.89 | Other combined immunodeficiencies | Can lead a claim | K | None |
| D81.9 | Combined immunodeficiency, unspecified | Can lead a claim | K | None |
Sources: CMS HH PPS Grouper Software v07.2.26, effective 2026-10-01, for the clinical group, comorbidity subgroup, code-first conventions and primary-position flags; CDC NCHS ICD-10-CM FY2027 code descriptions for the family title and code wording. This is the crosswalk Medicare runs a claim through. Grouping also depends on admission source, timing, the OASIS functional items and the rest of the diagnosis list.
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